TMEM251

Across TCGA patient cohorts, TMEM251 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM251-associated genes across cancer lineages are STAT3_pY705, VHL, and 4E-BP1. Each is linked with TMEM251 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM251-to-partner and partner-to-TMEM251 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by TMEM251-low versus TMEM251-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM251→partner) and Y-score (partner→TMEM251) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.527	-3.169	<.001	.020	3	1
UCEC	VHL →	-1.024	-3.169	.005	.019	3	1
UCEC	4E-BP1 →	+0.388	+2.837	.009	.035	2	1
UCEC	MEK1 →	+0.487	+3.169	.015	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

STAT3_pY705 by TMEM251 expression — UCEC

Explore this box plot interactively →