TMEM251

Across TCGA cell cohorts, TMEM251 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,419 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMEM251-associated GO terms across cancer lineages are Vesicle tethering to Golgi, tRNA threonylcarbamoyladenosine modification, and mRNA 3'-end processing by stem-loop binding and cleavage. Each is linked with TMEM251 in more than 9 cancer types. Because this analysis shows association rather than direction, both TMEM251-to-partner and partner-to-TMEM251 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle tethering to Golgi grouped by TMEM251-low versus TMEM251-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM251→partner) and Y-score (partner→TMEM251) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Vesicle tethering to Golgi →	+0.135	+0.775	.002	.002	3	9
LUNG_NSCLC_LUSC	tRNA threonylcarbamoyladenosine modification →	+0.126	+0.828	.005	.003	2	10
LUNG_NSCLC_LUSC	mRNA 3'-end processing by stem-loop binding and cleavage →	+0.157	+1.038	.002	.001	3	8
LARGE_INTESTINE	Negative regulation of protein folding →	+0.105	+0.699	<.001	<.001	3	8
LUNG_SCLC	Double-strand break repair →	+0.062	+0.628	<.001	<.001	2	9
CNS	Angiogenesis →	-0.059	-0.363	.001	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,419 associations by consensus.

Vesicle tethering to Golgi by TMEM251 expression — OESOPHAGUS

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