TMEM250

Across TCGA patient cohorts, TMEM250 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM250-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and CD4+ memory T-cells. Each is linked with TMEM250 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM250-to-partner and partner-to-TMEM250 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by TMEM250-low versus TMEM250-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM250→partner) and Y-score (partner→TMEM250) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ T-cells →	+0.029	+3.845	.005	.022	3	1
UCEC	CD8+ Tcm →	+0.073	+3.935	<.001	.020	3	1
UCEC	CD4+ memory T-cells →	+0.054	+3.202	<.001	.047	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD8+ T-cells by TMEM250 expression — UCEC

Explore this box plot interactively →