TMEM248

Across TCGA patient cohorts, TMEM248 protein abundance is significantly associated with the RNA expression of many other genes, with 2,724 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM248-associated genes across cancer lineages are E2F1, RPA3, and ZNHIT1. Each is linked with TMEM248 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM248-to-partner and partner-to-TMEM248 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM248 versus E2F1 in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM248→partner) and Y-score (partner→TMEM248) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	E2F1 →	+0.986	+0.440	<.001	<.001	3	2
LUAD	RPA3 →	+0.679	+0.413	<.001	.004	3	2
LUAD	ZNHIT1 →	+0.389	+0.398	.006	.002	3	2
LSCC	CENPF →	+1.004	+0.433	<.001	<.001	3	2
LSCC	MALSU1 →	+0.524	+0.521	<.001	<.001	3	2
LSCC	ZDHHC12 →	+0.590	+0.326	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,724 associations by consensus.

TMEM248 vs E2F1 — LSCC

Explore this scatter interactively →