TMEM248

Across TCGA patient cohorts, TMEM248 mutation is significantly associated with the RNA expression of many other genes, with 2,521 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM248-associated genes across cancer lineages are MIR6766, MIR7976, and RNA5SP124. Each is linked with TMEM248 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM248-to-partner and partner-to-TMEM248 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6766 grouped by TMEM248-low versus TMEM248-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM248→partner) and Y-score (partner→TMEM248) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MIR6766 →	+0.758	+3.831	<.001	.005	3	3
UCEC	MIR7976 →	+0.452	+2.453	<.001	.002	3	2
UCEC	RNA5SP124 →	+0.307	+1.929	.003	.008	3	2
UCEC	RPL21P66 →	+0.072	+2.801	.003	<.001	3	2
CESC	ODF3 →	+0.030	+3.721	.002	.006	3	2
CESC	TRAJ40 →	+0.471	+3.612	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,521 associations by consensus.

MIR6766 by TMEM248 expression — STAD

Explore this box plot interactively →