TMEM248

Across TCGA patient cohorts, TMEM248 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM248-associated genes across cancer lineages are FOXO3a_pS318_S321, MAPK_pT202_Y204, and mTOR_pS2448. Each is linked with TMEM248 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM248-to-partner and partner-to-TMEM248 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TMEM248-low versus TMEM248-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM248→partner) and Y-score (partner→TMEM248) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.165	-3.700	.004	.001	3	2
UCEC	MAPK_pT202_Y204 →	-0.470	-3.000	.031	.036	3	2
UCEC	mTOR_pS2448 →	-0.235	-3.308	<.001	.009	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.595	-3.000	.004	.036	2	3
UCEC	Annexin-1 →	+0.691	+3.189	.004	.010	3	2
UCEC	Smad3 →	+0.140	+2.999	.046	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FOXO3a_pS318_S321 by TMEM248 expression — UCEC

Explore this box plot interactively →