TMEM248

Across TCGA cell cohorts, TMEM248 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,792 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM248-associated GO terms across cancer lineages are Peptidyl-glutamic acid carboxylation, Protein carboxylation, and Cytosolic ribosome assembly. Each is linked with TMEM248 in more than 18 cancer types. Because this analysis shows association rather than direction, both TMEM248-to-partner and partner-to-TMEM248 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-glutamic acid carboxylation grouped by TMEM248-low versus TMEM248-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM248→partner) and Y-score (partner→TMEM248) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Peptidyl-glutamic acid carboxylation →	+0.176	+0.820	<.001	<.001	3	19
OESOPHAGUS	Protein carboxylation →	+0.176	+0.820	<.001	<.001	3	19
SKIN	Cytosolic ribosome assembly →	+0.107	+0.621	<.001	<.001	3	12
CNS	Endosomal transport →	+0.042	+0.534	<.001	.001	3	11
CNS	Positive regulation of protein localization to membrane →	+0.060	+0.468	.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.054	+0.713	.003	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,792 associations by consensus.

Peptidyl-glutamic acid carboxylation by TMEM248 expression — OESOPHAGUS

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