TMEM248

Across TCGA cell cohorts, TMEM248 mutation is significantly associated with the mutation status of many other genes, with 3,350 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM248-associated genes across cancer lineages are SMG5, PARP3, and PANX2. Each is linked with TMEM248 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM248-to-partner and partner-to-TMEM248 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMG5 grouped by TMEM248-low versus TMEM248-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM248→partner) and Y-score (partner→TMEM248) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMG5 →	+3.007	+3.584	.008	.008	1	4
BLOOD_Leukemia	PARP3 →	+4.894	+4.894	.004	.004	1	3
LARGE_INTESTINE	PANX2 →	+2.936	+4.471	.001	.001	1	3
BLOOD_Leukemia	ABCC8 →	+2.894	+4.432	.005	.005	1	3
SKIN	TRIP11 →	+4.239	+5.053	.007	.007	1	3
CNS	NYAP2 →	+4.614	+5.584	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,350 associations by consensus.

SMG5 by TMEM248 expression — LARGE_INTESTINE

Explore this box plot interactively →