TMEM247

Across TCGA cell cohorts, TMEM247 RNA expression is significantly associated with the mutation status of many other genes, with 34 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM247-associated genes across cancer lineages are NRAS, TRIM37, and ZNF521. Each is linked with TMEM247 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM247-to-partner and partner-to-TMEM247 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NRAS grouped by TMEM247-low versus TMEM247-high in BLOOD_Myeloma.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM247→partner) and Y-score (partner→TMEM247) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NRAS →	+2.263	+0.875	<.001	<.001	3	2
STOMACH	TRIM37 →	+3.247	+0.208	.003	.004	3	2
BLOOD_Leukemia	ZNF521 →	+3.569	+0.229	.009	.002	3	1
LUNG_SCLC	OTOF →	+3.353	+0.156	.001	<.001	3	1
LUNG_SCLC	PLEK →	+4.523	+0.256	.003	<.001	3	1
LUNG_SCLC	PALLD →	+4.523	+0.229	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

NRAS by TMEM247 expression — BLOOD_Myeloma

Explore this box plot interactively →