Across TCGA patient cohorts, TMEM246-AS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,801 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM246-AS1-associated proteins across cancer lineages are SH3BGRL2, TACC2_S962, and PTPN12. Each is linked with TMEM246-AS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM246-AS1-to-partner and partner-to-TMEM246-AS1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM246-AS1→partner) and Y-score (partner→TMEM246-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SH3BGRL2 →	+0.478	+0.744	<.001	<.001	3	5
LSCC	TACC2_S962 →	+0.821	+0.614	<.001	<.001	3	5
HNSC	PTPN12 →	-0.307	-0.628	<.001	<.001	3	5
GBM	NNMT →	-1.181	-0.762	<.001	.003	3	5
CCRCC	RUNX1_T14 →	-0.492	-1.585	<.001	<.001	3	4
HNSC	TACC2_S317 →	+1.466	+0.685	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,801 associations by consensus.

Exploration

TMEM246-AS1 survival (RNA) · tumor vs normal (RNA) · all TMEM246-AS1 data types