Across TCGA pan-cancer cohorts, TMEM239 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM239 data layer compared with 15 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM239 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM239 expression acts as an unfavorable survival marker.

UCEC and SKCM are the cancer types where TMEM239 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	All	0.180	0.622	.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TMEM239 tumor-vs-normal RNA expression · all TMEM239 data types