TMEM237

Across TCGA patient cohorts, TMEM237 mutation is significantly associated with the RNA expression of many other genes, with 1,359 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM237-associated genes across cancer lineages are KPNB1P1, CYCSP22, and MCAT. Each is linked with TMEM237 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM237-to-partner and partner-to-TMEM237 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KPNB1P1 grouped by TMEM237-low versus TMEM237-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM237→partner) and Y-score (partner→TMEM237) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	KPNB1P1 →	+0.048	+3.356	<.001	.007	3	2
READ	CYCSP22 →	+0.206	+5.421	<.001	.005	3	2
UCEC	MCAT →	+0.455	+2.265	.002	.006	3	2
UCEC	MTHFD1 →	+0.481	+2.650	.008	.005	3	2
UCEC	DNAJA3 →	+0.551	+2.781	<.001	.002	3	2
UCEC	RARS1 →	+0.403	+3.541	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,359 associations by consensus.

KPNB1P1 by TMEM237 expression — SKCM

Explore this box plot interactively →