TMEM237

Across TCGA cell cohorts, TMEM237 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TMEM237-associated genes across cancer lineages are CFHR2, MT4, and CHP2. Each is linked with TMEM237 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM237-to-partner and partner-to-TMEM237 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by TMEM237-low versus TMEM237-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM237→partner) and Y-score (partner→TMEM237) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1
CNS	MT4 →	+0.188	+4.321	<.001	.009	3	1
CNS	CHP2 →	+0.100	+4.315	<.001	.006	3	1
CNS	KRT74 →	+0.268	+4.315	<.001	.006	3	1
CNS	KLK15 →	+0.239	+4.169	<.001	.008	3	1
CNS	KRT73 →	+0.041	+5.044	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CFHR2 by TMEM237 expression — BLOOD_Leukemia

Explore this box plot interactively →