Across TCGA patient cohorts, TMEM232 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM232-associated genes across cancer lineages are 14-3-3_beta, MEK1, and N-Ras. Each is linked with TMEM232 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM232-to-partner and partner-to-TMEM232 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM232→partner) and Y-score (partner→TMEM232) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.133	-2.401	.001	.003	3	2
UCEC	MEK1 →	+0.512	+3.087	<.001	<.001	3	2
UCEC	N-Ras →	-0.140	-3.295	.003	.009	3	2
UCEC	Shc_pY317 →	-0.192	-2.700	.001	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.827	+1.906	<.001	.016	3	2
UCEC	EGFR_pY1068 →	-0.297	-2.415	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

TMEM232 survival (RNA) · tumor vs normal (RNA) · all TMEM232 data types