Across TCGA patient cohorts, TMEM231 mutation is significantly associated with the RNA expression of many other genes, with 277 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM231-associated genes across cancer lineages are CYP4F36P, C17orf98, and MIR7976. Each is linked with TMEM231 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM231-to-partner and partner-to-TMEM231 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM231→partner) and Y-score (partner→TMEM231) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYP4F36P →	+0.298	+2.427	.003	.006	3	1
UCEC	C17orf98 →	+0.516	+2.588	<.001	.009	3	1
UCEC	MIR7976 →	+0.529	+2.775	<.001	.002	3	1
UCEC	PMS2P10 →	+0.503	+3.483	<.001	.002	3	1
COAD	FRG2 →	+0.095	+5.283	<.001	.006	3	1
BLCA	MIR4276 →	+0.663	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 277 associations by consensus.

Exploration

TMEM231 survival (RNA) · tumor vs normal (RNA) · all TMEM231 data types