TMEM230

Across TCGA patient cohorts, TMEM230 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM230-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Annexin-1. Each is linked with TMEM230 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM230-to-partner and partner-to-TMEM230 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM230-low versus TMEM230-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM230→partner) and Y-score (partner→TMEM230) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.331	-3.000	.022	.037	1	1
UCEC	JNK_pT183_Y185 →	-0.233	-2.986	.016	.037	1	1
UCEC	Annexin-1 →	+0.671	+3.000	.027	.037	1	1
UCEC	STAT5a →	+0.488	+3.000	.034	.037	1	1
UCEC	c-Jun_pS73 →	-0.204	-3.000	.026	.037	1	1
UCEC	Cyclin-E2 →	+0.208	+3.000	.033	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR_pY1068 by TMEM230 expression — UCEC

Explore this box plot interactively →