Across TCGA patient cohorts, TMEM229B mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM229B-associated genes across cancer lineages are GSK-3a-b_pS21_S9, PDK1_pS241, and PRAS40_pT246. Each is linked with TMEM229B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM229B-to-partner and partner-to-TMEM229B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM229B→partner) and Y-score (partner→TMEM229B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.719	+2.817	.005	.036	3	1
UCEC	PDK1_pS241 →	+0.236	+2.820	.024	.036	3	1
UCEC	PRAS40_pT246 →	+0.274	+2.820	.009	.036	3	1
UCEC	AMPK_pT172 →	+0.516	+2.820	.040	.036	3	1
UCEC	Tuberin_pT1462 →	+0.515	+2.817	<.001	.036	3	1
UCEC	VEGFR2 →	+0.403	+2.820	.026	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

TMEM229B survival (RNA) · tumor vs normal (RNA) · all TMEM229B data types