TMEM225B

Across TCGA pan-cancer cohorts, TMEM225B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TMEM225B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM225B RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM225B is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and UCEC are the cancer types where TMEM225B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM225B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.330	<.001	8	view →
LUAD	All	All	−0.227	<.001	7	view →
UCEC	All	All	−1.310	<.001	6	view →
BRCA	All	III,IV	−0.708	<.001	6	view →
KIRP	Male	II,III,IV	−0.393	.020	4	view →
LIHC	All	All	+0.304	<.001	4	view →
STAD	All	II,III,IV	−0.186	.023	4	view →
CHOL	All	All	+0.480	<.001	3	view →
THCA	All	All	+0.360	<.001	3	view →
COAD	All	III,IV	−0.214	.031	3	view →
LUSC	All	III,IV	−0.520	.001	2	view →
PRAD	All	All	−0.396	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TMEM225B–KIRC

Open the KIRC breakdown →