TMEM223

Across TCGA pan-cancer cohorts, TMEM223 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM223 data layer compared with 28 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM223 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM223 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where TMEM223 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.719	0.506	.016	10	view →
PDAC	DFS	Quartile	All	0.304	0.534	.010	9	view →
UCEC	OS	Quartile	III,IV	0.807	0.250	.020	8	view →
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM223–HNSC (DFS)

Open the HNSC breakdown →