TMEM223

Across TCGA patient cohorts, TMEM223 protein abundance is significantly associated with the RNA expression of many other genes, with 8,137 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM223-associated genes across cancer lineages are ANTXR2, SLC50A1, and RELA-DT. Each is linked with TMEM223 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM223-to-partner and partner-to-TMEM223 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM223 versus ANTXR2 in UCEC, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM223→partner) and Y-score (partner→TMEM223) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANTXR2 →	-1.112	-0.467	<.001	<.001	3	3
LSCC	SLC50A1 →	+0.499	+0.360	<.001	<.001	3	3
LSCC	RELA-DT →	+0.527	+0.333	<.001	<.001	3	3
LSCC	COL16A1 →	-0.928	-0.371	<.001	<.001	3	3
OV	GGT5 →	-0.930	-0.413	.005	<.001	3	3
UCEC	CPED1 →	-0.769	-0.331	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,137 associations by consensus.

TMEM223 vs ANTXR2 — UCEC

Explore this scatter interactively →