TMEM223

Across TCGA patient cohorts, TMEM223 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM223-associated genes across cancer lineages are OR5L1, SNORD115-8, and RNU7-147P. Each is linked with TMEM223 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM223-to-partner and partner-to-TMEM223 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5L1 grouped by TMEM223-low versus TMEM223-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM223→partner) and Y-score (partner→TMEM223) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR5L1 →	+0.039	+7.731	<.001	.009	3	1
LUAD	SNORD115-8 →	+0.341	+7.930	<.001	.008	3	1
LUAD	RNU7-147P →	+0.603	+7.930	<.001	.008	3	1
UCEC	MIR8070 →	+1.086	+3.132	<.001	.007	3	1
BRCA	RNA5SP24 →	+0.357	+7.731	<.001	.009	3	1
BRCA	RNU2-57P →	+0.167	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

OR5L1 by TMEM223 expression — BRCA

Explore this box plot interactively →