TMEM223

Across TCGA patient cohorts, TMEM223 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM223-associated genes across cancer lineages are Preadipocytes, CD8+ T-cells, and CD8+ Tcm. Each is linked with TMEM223 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM223-to-partner and partner-to-TMEM223 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Preadipocytes grouped by TMEM223-low versus TMEM223-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM223→partner) and Y-score (partner→TMEM223) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Preadipocytes →	+0.056	+4.169	.002	.027	3	2
UCEC	CD8+ T-cells →	+0.021	+3.430	.007	.007	3	1
UCEC	CD8+ Tcm →	+0.060	+4.350	<.001	<.001	3	1
UCEC	Macrophages M1 →	+0.019	+2.864	.049	.049	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Preadipocytes by TMEM223 expression — COAD

Explore this box plot interactively →