TMEM223

Across TCGA cell cohorts, TMEM223 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,072 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM223-associated GO terms across cancer lineages are Mitochondrial electron transport, succinate to ubiquinone, CAAX-box protein processing, and Mitochondrial respiratory chain complex IV assembly. Each is linked with TMEM223 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM223-to-partner and partner-to-TMEM223 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial electron transport, succinate to ubiquinone grouped by TMEM223-low versus TMEM223-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM223→partner) and Y-score (partner→TMEM223) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Mitochondrial electron transport, succinate to ubiquinone →	+0.100	+0.705	<.001	<.001	3	12
BONE	CAAX-box protein processing →	+0.125	+0.565	<.001	<.001	3	11
LIVER	Mitochondrial respiratory chain complex IV assembly →	+0.092	+0.704	.001	<.001	3	11
BONE	Spliceosomal conformational changes to generate catalytic conformation →	+0.085	+0.672	<.001	<.001	3	10
BLOOD_Lymphoma	Cytochrome complex assembly →	+0.051	+0.567	<.001	.001	3	10
LARGE_INTESTINE	Regulation of mRNA processing →	+0.068	+0.648	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,072 associations by consensus.

Mitochondrial electron transport, succinate to ubiquinone by TMEM223 expression — STOMACH

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