Across TCGA patient cohorts, TMEM222 protein abundance is significantly associated with the RNA expression of many other genes, with 10,379 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM222-associated genes across cancer lineages are ANP32B, SLC13A4, and STAG3L2. Each is linked with TMEM222 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM222-to-partner and partner-to-TMEM222 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM222→partner) and Y-score (partner→TMEM222) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANP32B →	-0.782	-0.307	<.001	<.001	3	4
LSCC	SLC13A4 →	-0.647	-0.276	.001	.001	3	4
HNSC	STAG3L2 →	-0.704	-0.222	.001	.003	3	4
UCEC	CENPF →	-1.282	-0.643	<.001	<.001	3	4
UCEC	ASPM →	-1.062	-0.543	<.001	.002	3	4
LUAD	TPX2 →	-1.109	-0.233	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,379 associations by consensus.

Exploration

TMEM222 survival (RNA) · tumor vs normal (RNA) · all TMEM222 data types