Across TCGA patient cohorts, TMEM222 mutation is significantly associated with the RNA expression of many other genes, with 108 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM222-associated genes across cancer lineages are RNU5E-9P, SNORD11B, and FAM133CP. Each is linked with TMEM222 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM222-to-partner and partner-to-TMEM222 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM222→partner) and Y-score (partner→TMEM222) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU5E-9P →	+0.328	+4.470	<.001	.004	3	2
UCEC	SNORD11B →	+0.637	+2.646	.001	.004	3	1
UCEC	FAM133CP →	+0.335	+3.994	<.001	.001	3	1
UCEC	PPP6C →	+0.623	+3.210	.002	.009	3	1
UCEC	USP15 →	+0.482	+3.210	.006	.009	3	1
BLCA	RNA5SP524 →	+0.248	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

Exploration

TMEM222 survival (RNA) · tumor vs normal (RNA) · all TMEM222 data types