Across TCGA cell cohorts, TMEM222 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM222-associated genes across cancer lineages are OR2M5, MROH2B, and TMEM244. Each is linked with TMEM222 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM222-to-partner and partner-to-TMEM222 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM222→partner) and Y-score (partner→TMEM222) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M5 →	+0.032	+5.415	<.001	.004	3	1
LARGE_INTESTINE	MROH2B →	+0.006	+5.415	<.001	.004	3	1
LARGE_INTESTINE	TMEM244 →	+0.691	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR4D10 →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	PRAMEF27 →	+0.006	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

TMEM222 survival (RNA) · tumor vs normal (RNA) · all TMEM222 data types