Across TCGA patient cohorts, TMEM221 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,384 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM221-associated proteins across cancer lineages are PALM, SEPTIN11, and GSTM2. Each is linked with TMEM221 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM221-to-partner and partner-to-TMEM221 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM221→partner) and Y-score (partner→TMEM221) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PALM →	+0.653	+0.460	<.001	<.001	3	4
PDAC	SEPTIN11 →	+0.267	+0.139	.001	.005	3	4
LSCC	GSTM2 →	+0.896	+0.471	<.001	<.001	3	4
GBM	HOPX →	+0.732	+0.541	<.001	<.001	3	4
LSCC	MAP1B_S2271 →	+0.825	+0.398	<.001	<.001	3	4
LUAD	MAP1S →	+0.206	+0.166	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,384 associations by consensus.

Exploration

TMEM221 survival (RNA) · tumor vs normal (RNA) · all TMEM221 data types