Across TCGA patient cohorts, TMEM221 protein abundance is significantly associated with the RNA expression of many other genes, with 242 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM221-associated genes across cancer lineages are SLC6A13, GFUS, and CLCN6. Each is linked with TMEM221 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM221-to-partner and partner-to-TMEM221 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM221→partner) and Y-score (partner→TMEM221) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC6A13 →	-0.682	-0.736	.003	<.001	3	1
GBM	GFUS →	+0.432	+0.645	.001	.001	3	1
GBM	CLCN6 →	-0.763	-0.931	<.001	.002	3	1
GBM	SLC5A9 →	-1.578	-0.774	<.001	<.001	3	1
GBM	MCF2L →	-0.821	-0.638	.005	.002	3	1
GBM	FCRLA →	+0.808	+0.818	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 242 associations by consensus.

Exploration

TMEM221 survival (RNA) · tumor vs normal (RNA) · all TMEM221 data types