Across TCGA patient cohorts, TMEM220 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM220-associated genes across cancer lineages are PRAMEF13, RNA5SP412, and RNU6-756P. Each is linked with TMEM220 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM220-to-partner and partner-to-TMEM220 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM220→partner) and Y-score (partner→TMEM220) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAMEF13 →	+0.048	+4.132	<.001	.009	3	1
UCEC	RNA5SP412 →	+1.008	+4.289	<.001	<.001	3	1
BLCA	RNU6-756P →	+0.333	+7.640	<.001	.009	3	1
BLCA	LSM1P2 →	+0.129	+7.640	<.001	.009	3	1
UCEC	OR1R1P →	+0.097	+3.474	.005	.006	3	1
UCEC	RNU6-992P →	+0.213	+4.555	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

TMEM220 survival (RNA) · tumor vs normal (RNA) · all TMEM220 data types