TMEM220-AS1

Across TCGA pan-cancer cohorts, TMEM220-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMEM220-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMEM220-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM220-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LIHC show a favorable association.

KIRC, LIHC, and LGG are the cancer types where TMEM220-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.705	0.551	<.001	114	view →
LIHC	OS	Median	All	0.769	0.604	<.001	81	view →
LGG	DFS	Median	All	0.630	0.840	<.001	52	view →
UCS	DFS	Tertile	III,IV	0.545	0.097	.001	46	view →
KIRP	DFS	Median	II,III,IV	0.875	0.641	.005	42	view →
LUSC	DFS	Median	II,III,IV	0.628	0.797	<.001	37	view →
HNSC	DFS	Median	IV	0.709	0.576	.010	35	view →
SARC	OS	Median	All	0.902	0.768	<.001	30	view →
OV	OS	Quartile	III,IV	0.916	0.803	.013	28	view →
LAML	DFS	Median	All	0.744	0.399	<.001	28	view →
SKCM	OS	Quartile	All	0.184	0.535	<.001	25	view →
ACC	DFS	Quartile	III,IV	0.682	0.065	.001	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMEM220-AS1–KIRC (OS)

Open the KIRC breakdown →