TMEM219

Across TCGA patient cohorts, TMEM219 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM219-associated genes across cancer lineages are TTTY7B, MIR548AP, and EIF2S2P7. Each is linked with TMEM219 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM219-to-partner and partner-to-TMEM219 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY7B grouped by TMEM219-low versus TMEM219-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM219→partner) and Y-score (partner→TMEM219) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTTY7B →	+0.024	+8.471	<.001	.005	3	2
BRCA	MIR548AP →	+0.322	+8.055	<.001	.007	3	1
UCEC	EIF2S2P7 →	+0.138	+4.677	<.001	<.001	3	1
UCEC	MIR98 →	+0.607	+3.801	<.001	.004	3	1
UCEC	H4C7 →	+0.252	+4.077	.004	.001	3	1
UCEC	RNA5SP411 →	+2.639	+3.393	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

TTTY7B by TMEM219 expression — BRCA

Explore this box plot interactively →