TMEM219

Across TCGA cell cohorts, TMEM219 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,311 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM219-associated GO terms across cancer lineages are Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Ribosomal large subunit biogenesis, and Maturation of LSU-rRNA. Each is linked with TMEM219 in more than 14 cancer types. Because this analysis shows association rather than direction, both TMEM219-to-partner and partner-to-TMEM219 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by TMEM219-low versus TMEM219-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM219→partner) and Y-score (partner→TMEM219) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.118	-0.694	<.001	<.001	3	15
OESOPHAGUS	Ribosomal large subunit biogenesis →	-0.115	-0.880	.003	.005	3	14
OESOPHAGUS	Maturation of LSU-rRNA →	-0.140	-1.065	<.001	.003	3	13
OESOPHAGUS	Ribosome biogenesis →	-0.112	-1.115	<.001	.001	3	13
OESOPHAGUS	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.131	-1.066	<.001	<.001	3	13
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	-0.133	-0.727	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,311 associations by consensus.

Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by TMEM219 expression — LARGE_INTESTINE

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