TMEM218

Across TCGA pan-cancer cohorts, TMEM218 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated TMEM218 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM218 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM218 expression acts as an unfavorable survival marker.

HNSC are the cancer types where TMEM218 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.170	0.696	.010	18	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

TMEM218–HNSC (DFS)

Open the HNSC breakdown →