TMEM218

Across TCGA patient cohorts, TMEM218 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,044 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM218-associated proteins across cancer lineages are RNF214, VPS26B, and THYN1. Each is linked with TMEM218 in more than 7 cancer types. Because this analysis shows association rather than direction, both TMEM218-to-partner and partner-to-TMEM218 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM218 versus RNF214 in OV, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM218→partner) and Y-score (partner→TMEM218) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RNF214 →	+0.275	+0.383	<.001	.006	3	8
OV	VPS26B →	+0.423	+0.394	<.001	<.001	3	7
OV	THYN1 →	+0.622	+0.364	.001	.006	3	6
LSCC	MRE11 →	+0.287	+0.351	<.001	<.001	3	6
PDAC	UBE4A →	+0.269	+0.332	<.001	<.001	3	5
LSCC	ARHGAP32_S892 →	+0.948	+0.305	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,044 associations by consensus.

TMEM218 vs RNF214 — OV

Explore this scatter interactively →