Across TCGA patient cohorts, TMEM216 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,157 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM216-associated proteins across cancer lineages are CPSF7, DDB1, and DMXL1. Each is linked with TMEM216 in more than 6 cancer types. Because this analysis shows association rather than direction, both TMEM216-to-partner and partner-to-TMEM216 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM216→partner) and Y-score (partner→TMEM216) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CPSF7 →	+0.368	+0.450	<.001	.006	3	7
CCRCC	DDB1 →	+0.161	+0.281	.002	.007	3	5
LSCC	DMXL1 →	-0.227	-0.591	<.001	<.001	3	5
GBM	IRF2BP1 →	+0.265	+0.369	<.001	<.001	3	5
HNSC	WIZ →	+0.276	+0.805	<.001	<.001	3	5
HNSC	VEZF1 →	+0.441	+0.939	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,157 associations by consensus.

Exploration

TMEM216 survival (RNA) · tumor vs normal (RNA) · all TMEM216 data types