Across TCGA patient cohorts, TMEM216 mutation is significantly associated with the RNA expression of many other genes, with 113 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM216-associated genes across cancer lineages are CTCF, CMC2, and PROSER1. Each is linked with TMEM216 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM216-to-partner and partner-to-TMEM216 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM216→partner) and Y-score (partner→TMEM216) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTCF →	+0.643	+3.234	.002	.009	3	1
UCEC	CMC2 →	+0.626	+3.235	<.001	.009	3	1
UCEC	PROSER1 →	+0.687	+3.210	.002	.009	3	1
LUSC	RNU6-753P →	+0.302	+7.924	<.001	.008	3	1
LUSC	RNU6-1072P →	+0.303	+7.924	<.001	.008	3	1
UCEC	TVP23CP2 →	+0.309	+3.117	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

Exploration

TMEM216 survival (RNA) · tumor vs normal (RNA) · all TMEM216 data types