Across TCGA patient cohorts, TMEM215 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM215-associated genes across cancer lineages are Gab2, p21, and Stathmin. Each is linked with TMEM215 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM215-to-partner and partner-to-TMEM215 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM215→partner) and Y-score (partner→TMEM215) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.354	+3.321	.004	.010	3	2
UCEC	p21 →	+0.204	+2.906	.002	.001	3	2
UCEC	Stathmin →	+0.118	+1.362	.014	.037	3	2
UCEC	ASNS →	+0.300	+1.584	.019	.034	3	2
UCEC	C-Raf →	+0.207	+2.502	<.001	.001	3	2
COAD	MIG-6 →	+0.115	+3.519	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

TMEM215 survival (RNA) · tumor vs normal (RNA) · all TMEM215 data types