Across TCGA cell cohorts, TMEM215 mutation is significantly associated with the mutation status of many other genes, with 36 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TMEM215-associated genes across cancer lineages are OR2T2, SLC22A24, and OR10R2. Each is linked with TMEM215 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM215-to-partner and partner-to-TMEM215 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM215→partner) and Y-score (partner→TMEM215) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR2T2 →	+5.066	+4.502	.007	.007	1	1
LUNG_SCLC	SLC22A24 →	+5.066	+4.502	.007	.007	1	1
LUNG_SCLC	OR10R2 →	+5.651	+5.651	<.001	<.001	1	1
LUNG_SCLC	IZUMO3 →	+5.066	+4.502	.007	.007	1	1
LUNG_SCLC	RTL1 →	+3.066	+4.369	.005	.005	1	1
LUNG_SCLC	ANKRD20A1 →	+5.066	+4.502	.007	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

TMEM215 survival (RNA) · tumor vs normal (RNA) · all TMEM215 data types