TMEM214

Across TCGA patient cohorts, TMEM214 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM214-associated genes across cancer lineages are p70-S6K, EGFR_pY1068, and A-Raf_pS299. Each is linked with TMEM214 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM214-to-partner and partner-to-TMEM214 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by TMEM214-low versus TMEM214-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM214→partner) and Y-score (partner→TMEM214) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.152	+1.529	.031	.018	3	2
UCEC	EGFR_pY1068 →	-0.273	-2.906	.003	.001	3	1
UCEC	A-Raf_pS299 →	-0.140	-3.807	.001	<.001	3	1
UCEC	ERK2 →	+0.171	+1.502	.015	.030	3	1
UCEC	FOXO3a →	-0.074	-1.489	.047	.030	3	1
UCEC	Heregulin →	-0.138	-3.446	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p70-S6K by TMEM214 expression — UCEC

Explore this box plot interactively →