TMEM214

Across TCGA cell cohorts, TMEM214 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,910 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM214-associated GO terms across cancer lineages are Endoplasmic reticulum to cytosol transport, Retrograde protein transport, ER to cytosol, and Protein exit from endoplasmic reticulum. Each is linked with TMEM214 in more than 13 cancer types. Because this analysis shows association rather than direction, both TMEM214-to-partner and partner-to-TMEM214 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to cytosol transport grouped by TMEM214-low versus TMEM214-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM214→partner) and Y-score (partner→TMEM214) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Endoplasmic reticulum to cytosol transport →	+0.183	+1.120	<.001	<.001	3	14
BONE	Retrograde protein transport, ER to cytosol →	+0.183	+1.120	<.001	<.001	3	14
BONE	Protein exit from endoplasmic reticulum →	+0.179	+1.059	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	COPI-coated vesicle budding →	+0.136	+1.144	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Golgi transport vesicle coating →	+0.136	+1.144	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	COPI coating of Golgi vesicle →	+0.136	+1.144	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,910 associations by consensus.

Endoplasmic reticulum to cytosol transport by TMEM214 expression — BONE

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