Across TCGA pan-cancer cohorts, TMEM213 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM213’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM213 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM213 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC, KIRP, and HNSC are the cancer types where TMEM213 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM213 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.