Across TCGA pan-cancer cohorts, TMEM212 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated TMEM212 data layer compared with 1 for mutation status and 1 for mass-spec protein.
The strongest signal is observed in thymoma (THYM), where higher TMEM212 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM212 expression acts as an unfavorable survival marker, although some lineages such as LAML and SCLC show a favorable association.
THYM, BLCA, and LGG are the cancer types where TMEM212 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.