TMEM212-IT1

Across TCGA pan-cancer cohorts, TMEM212-IT1 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated TMEM212-IT1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM212-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM212-IT1 expression acts as an unfavorable survival marker, although some lineages such as LAML show a favorable association.

UCEC, KIRC, and SKCM are the cancer types where TMEM212-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.630	0.844	<.001	108	view →
KIRC	OS	Tertile	All	0.316	0.637	<.001	102	view →
SKCM	DFS	Tertile	All	0.284	0.627	<.001	84	view →
THYM	DFS	Tertile	III,IV	0.205	0.774	.007	45	view →
LAML	DFS	Tertile	All	0.579	0.317	.011	36	view →
GBM	OS	Tertile	All	0.075	0.413	.003	18	view →
HNSC	DFS	Tertile	All	0.428	0.634	.021	9	view →
SARC	DFS	Tertile	All	0.101	0.591	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TMEM212-IT1–UCEC (DFS)

Open the UCEC breakdown →