TMEM208

Across TCGA cell cohorts, TMEM208 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,670 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM208-associated GO terms across cancer lineages are Lysosomal lumen acidification, Endoplasmic reticulum organization, and Nitric oxide biosynthetic process. Each is linked with TMEM208 in more than 9 cancer types. Because this analysis shows association rather than direction, both TMEM208-to-partner and partner-to-TMEM208 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosomal lumen acidification grouped by TMEM208-low versus TMEM208-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM208→partner) and Y-score (partner→TMEM208) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Lysosomal lumen acidification →	+0.073	+0.475	.003	<.001	3	10
CNS	Endoplasmic reticulum organization →	+0.048	+0.632	.001	<.001	3	8
BONE	Nitric oxide biosynthetic process →	+0.155	+0.845	.007	<.001	2	7
BREAST	Vesicle uncoating →	+0.144	+0.606	<.001	.003	3	6
KIDNEY	Epithelial to mesenchymal transition →	-0.059	-0.511	.003	<.001	3	6
KIDNEY	tRNA dihydrouridine synthesis →	+0.136	+0.726	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,670 associations by consensus.

Lysosomal lumen acidification by TMEM208 expression — CNS

Explore this box plot interactively →