Across TCGA pan-cancer cohorts, TMEM207 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TMEM207’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM207 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM207 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where TMEM207 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM207 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−4.534	<.001	12	view →
KIRP	All	IV	−4.365	<.001	11	view →
KICH	Male	II,III,IV	−4.848	<.001	10	view →
LUSC	Male	III,IV	−0.080	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TMEM207 RNA expression & survival · all TMEM207 data types