Across TCGA patient cohorts, TMEM200C mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM200C-associated genes across cancer lineages are ATM, mTOR_pS2448, and P-Cadherin. Each is linked with TMEM200C in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM200C-to-partner and partner-to-TMEM200C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM200C→partner) and Y-score (partner→TMEM200C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.721	-2.986	<.001	.035	3	3
UCEC	mTOR_pS2448 →	-0.214	-3.302	.002	.010	3	2
UCEC	P-Cadherin →	-0.161	-3.169	.020	.018	3	2
UCEC	ASNS →	+0.543	+2.459	.001	.020	3	2
UCEC	Bax →	+0.308	+2.999	.007	.035	3	2
UCEC	FOXO3a_pS318_S321 →	-0.136	-2.459	.024	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

TMEM200C survival (RNA) · tumor vs normal (RNA) · all TMEM200C data types