TMEM199

Across TCGA pan-cancer cohorts, TMEM199 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM199 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM199 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM199 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, GBM, and PDAC are the cancer types where TMEM199 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.763	0.505	<.001	55	view →
GBM	OS	Quartile	All	0.805	0.441	.008	6	view →
PDAC	DFS	Quartile	III,IV	0.642	0.323	.042	2	view →
LUAD	DFS	Quartile	All	0.621	0.832	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM199–HNSC (DFS)

Open the HNSC breakdown →