TMEM199

Across TCGA patient cohorts, TMEM199 mutation is significantly associated with the RNA expression of many other genes, with 1,139 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM199-associated genes across cancer lineages are SCARNA23, SNORD116-10, and NKAP. Each is linked with TMEM199 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM199-to-partner and partner-to-TMEM199 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCARNA23 grouped by TMEM199-low versus TMEM199-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM199→partner) and Y-score (partner→TMEM199) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SCARNA23 →	+0.336	+3.129	.005	.004	3	2
SKCM	SNORD116-10 →	+0.234	+5.039	<.001	.003	3	2
UCEC	NKAP →	+0.423	+3.218	.003	.009	3	2
UCEC	NUP93 →	+0.485	+3.917	.004	<.001	3	2
UCEC	KLHL18 →	+0.453	+2.818	<.001	.001	3	2
UCEC	UPF3B →	+0.556	+2.524	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,139 associations by consensus.

SCARNA23 by TMEM199 expression — LUSC

Explore this box plot interactively →