TMEM199

Across TCGA patient cohorts, TMEM199 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM199-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Notch1. Each is linked with TMEM199 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM199-to-partner and partner-to-TMEM199 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM199-low versus TMEM199-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM199→partner) and Y-score (partner→TMEM199) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.303	-2.459	.012	.020	3	1
UCEC	JNK2 →	+0.237	+2.834	.013	.034	3	1
UCEC	Notch1 →	+0.259	+3.335	<.001	.005	3	1
UCEC	PCNA →	+0.216	+3.169	.039	.019	3	1
UCEC	STAT3_pY705 →	-0.501	-2.321	<.001	.033	3	1
UCEC	4E-BP1 →	+0.418	+3.199	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by TMEM199 expression — UCEC

Explore this box plot interactively →