TMEM199

Across TCGA cell cohorts, TMEM199 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,872 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM199-associated GO terms across cancer lineages are Spindle elongation, Mitotic nuclear division, and Positive regulation of mitotic cytokinesis. Each is linked with TMEM199 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM199-to-partner and partner-to-TMEM199 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by TMEM199-low versus TMEM199-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM199→partner) and Y-score (partner→TMEM199) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Spindle elongation →	+0.149	+0.588	<.001	<.001	3	12
BONE	Mitotic nuclear division →	+0.107	+0.831	.002	<.001	3	11
BLOOD_Myeloma	Positive regulation of mitotic cytokinesis →	+0.147	+0.873	<.001	.001	2	12
SOFT_TISSUE	DNA replication →	+0.087	+0.655	.004	.006	3	11
BLOOD_Myeloma	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.139	+0.834	<.001	<.001	3	11
BLOOD_Myeloma	rRNA 5'-end processing →	+0.139	+0.834	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,872 associations by consensus.

Spindle elongation by TMEM199 expression — BLOOD_Leukemia

Explore this box plot interactively →